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在抗菌素及其它药品的生产过程中,一种常用方法是将药瓶中的冻液冷冻干燥,首先用一个球模型描述了冻核逐渐变小的冷冻干燥过程,模拟了对脱水物质能产生最大温度驱动力,而且质量和设备性能都已给定情况下的冷冻干燥工艺,指出双重控制真空度和加热功率是一种可行的冷冻干燥方法。利用这种方法,常规那种在药瓶中进行冷冻干燥所需要的冷冻干燥时间可明显缩短。最后讨论了用该操怍方法出现的一些问题。
In the production of antibiotics and other drugs, a commonly used method is to freeze-dry the liquid in the vial. First, a spherical model is used to describe the freeze-drying process in which the freezing nuclei progressively taper, simulating the maximum amount of dehydration material produced Temperature driving force, and the quality and equipment performance have been given freeze-drying process, pointed out that the dual control of vacuum and heating power is a viable freeze-drying method. With this method, the freeze-drying time required for conventional freeze-drying in vials can be significantly reduced. Finally, we discuss some problems that arise with this method.