论文部分内容阅读
目的 观察不同场强的电磁脉冲(electromagnetic pulse,EMP)照射对大鼠学习能力的影响,并采取一定的屏蔽措施,探讨其物理防护作用。方法Wistar大鼠45只,随机分为4组,分别为60 kV·m-1照射组、20 kV·m-1照射组、物理防护组和对照组;物理防护组在镀铜织物防护布的屏蔽下接受60 kV·m-1照射,对照组接受相同时间的伪照射;各组于照射后即刻开始进行连续8 d的穿梭箱训练,记录每天的成绩,绘制学习曲线。结果 EMP照射后,60 kv·m-1照射组的主动回避反应(AV)次数明显降低,第8天分别较对照组和物理防护组下降24.1％和22.4％(P<0.05);20 kV·m-1照射组的AV值也低于对照和物理防护组,但差别不显著(P>0.05)。60 kv·m-1照射组的被动逃避反应(ESC)及主动回避反应潜伏期(AVLAT)则明显增高,第8天分别较对照组和防护组增高62.7％和53.9％,以及69.7％和1 9.5％(P<0.05)。各组间的被动逃避反应潜伏期(ESCLAT)无统计学差异。结论EMP照射可抑制大鼠的学习能力,表现为条件反射形成滞后和主动反应潜伏期延长,而且此效应存在一定的量效关系,表现为60 kv·m-1场强EMP作用明显,而20 kV·m-1场强EMP作用较弱;物理防护可较有效地减轻上述损伤效应。
Objective To observe the effects of electromagnetic field (EMP) irradiation with different field strength on learning ability of rats and take some shielding measures to explore its physical protective effect. Methods Forty-five Wistar rats were randomly divided into 4 groups: 60 kV · m-1 irradiation group, 20 kV · m-1 irradiation group, physical protection group and control group. Physical protection group Under the shielding, 60 kV · m-1 irradiation was performed, and the control group received the same irradiation time; each group began to train continuously for 8 days after the irradiation, recording daily scores and drawing learning curve. Results After EMP irradiation, the frequency of active avoidance (AV) in 60 kv · m-1 irradiation group was significantly lower than that in control group and physical protection group by 24.1% and 22.4% on the 8th day (P <0.05) AV values in m-1 irradiation group were also lower than those in control group and physical protection group, but the difference was not significant (P> 0.05). The passive avoidance response (ESC) and active avoidance response latency (AVLAT) in 60 kv · m-1 irradiation group were significantly higher than those in control group and protection group on the 8th day (62.7% vs 53.9%, respectively) and 69.7% % (P <0.05). Passive evasive response latency (ESCLAT) between groups was not statistically different. Conclusion EMP irradiation can inhibit the learning ability of rats, showing the lag of conditioned reflex and the prolonged latency of active reaction, and there is a certain dose-effect relationship between the effects of EMP irradiation and EMP irradiation. The effect of EMP on 60kv · m- · The effect of EMP on m-1 field strength is weak; physical protection can reduce the damage effect more effectively.