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目的观察使用文蛤膏外敷配合三阶梯药物止痛治疗癌症疼痛(癌痛)的临床疗效。方法选择2013年1月—2014年12月收治的100例癌痛患者作为研究对象,随机分为对照组和治疗组各50例。对照组给予三阶梯药物止痛治疗(第一阶梯:阿司匹林50 mg/次,口服,3次/d;第二阶梯:氨酚待因1~2片/次,口服,3次/d;第三阶梯:硫酸吗啡控释片10~30 mg/次,口服,1次/d),治疗组在对照组的基础上给予文蛤膏外敷治疗,6 h/次,1次/d,连用2周。观察并比较两组治疗效果及爆发痛发作情况。计量资料采用t检验,计数资料采用χ2检验,P<0.05为差异有统计学意义。结果治疗组缓解轻度、中度癌痛的总有效率分别为94.74%、93.75%,均明显高于对照组的61.90%、58.82%,差异均有统计学意义(均P<0.05)。对照组平均爆发痛发作次数为(1.83±1.62)次/(人·d);治疗组为(0.79±0.81)次/(人·d);两组比较差异有统计学意义(P<0.05)。结论文蛤膏外敷配合三阶梯止痛药物治疗癌痛的效果比较明显,具有较好的止痛作用,值得在临床上普遍推广使用。
Objective To observe the clinical effect of using clam plaster topical with three-step medicine to relieve pain (cancer pain). Methods A total of 100 patients with cancer pain treated in our hospital from January 2013 to December 2014 were selected and randomly divided into control group and treatment group of 50 cases each. The control group was given three-step analgesic treatment (first step: aspirin 50 mg / time, orally, 3 times / d; the second step: paracetamol was 1 to 2 tablets / time, Step: Morphine sulfate controlled-release tablets 10 ~ 30 mg / time, orally, once / d). The treatment group was given the external application of occidental medicine on the basis of the control group, 6 h / time, once daily for 2 weeks. Observed and compared the treatment effect and the onset of painful episodes. Measurement data using t test, count data using χ2 test, P <0.05 for the difference was statistically significant. Results The total effective rate of mild to moderate cancer pain in the treatment group was 94.74% and 93.75%, respectively, which were significantly higher than those in the control group (61.90% and 58.82%, both P <0.05). (1.83 ± 1.62) times / (person · d) in the control group; (0.79 ± 0.81) times / (person · d) in the treatment group; the difference between the two groups was statistically significant (P0.05) . Conclusion The effect of applying clam plaster topical and three-step analgesic drugs in the treatment of cancer pain is obvious. It has good analgesic effect and is worth popularizing in clinic.