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目的:探讨聚合物纳米体系在药物和基因载体中的应用。方法:含有共价结合药物的纳米聚合物在结构上更接近于一个化学体,可以借助聚合物以共价键连接,有利于实现定位、定时的释放,因而在药物释放前不会对人体产生伤害。结果:对病人的损伤达到较小;多功能聚合物还可以隐蔽生物活性物质比如蛋白质多肽等,使其具有EPR效应,使其可以进入到带有疾病部位的血管或者是炎症组织处且不影响到正常的组织。结论:药物在带有疾病处释放,能够减少副作用的发生。
Objective: To investigate the application of polymer nanomaterials in drug and gene carrier. METHODS: Nanopolymers containing covalently bonded drugs are structurally closer to a chemical entity that can be covalently linked by means of a polymer, which facilitates positioning and timing release and thus does not produce on the human body prior to drug release hurt. Results: Lesion damage to patients is small; Multifunctional polymers can also conceal bioactive substances such as protein polypeptides, so that it has the EPR effect, allowing it to enter the site of disease with vascular or inflammatory tissue and does not affect To normal tissue. Conclusion: Drugs released at a disease site can reduce the incidence of side effects.