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目的：观察吉西他滨和顺铂联合放疗治疗中晚期鼻咽癌的临床疗效及其毒副反应。方法：2012年1月至2013年12月对39例鼻咽癌采取吉西他滨1000mg/m2,d1、8,顺铂20mg/m2,d1-5,每3周为一周期,两周期后序贯放疗70~72gy/7~8周。结果：39例患者中,cr16例, pr18例,有效率为87.1%,主要毒副作用是骨髓抑制,其他毒副作用均较轻,可耐受,不影响治疗。结论：吉西他滨和顺铂联合放疗治疗中晚期鼻咽癌是一较好方案,毒副反应较轻。“,”objective:objective to evaluate the ef iciency and toxicity of gemcitabine and cisplatin with radiotherapy in the treatment of nasopharyngeal carcinoma. methods:from january 2006 to december 2007,39 patients with nasopharyngeal poorly dif erentiated squamous cellcancer were enrol ed in study. gemcitabine 1000mg/m2,d1、8;cisplatin 20mg/m2,d1-5,every 3 weeks,after 2 cycle,radiotherapy 70~72gy/7~8weeks. results:al eligible patients were assessed for response and 16 achieved a complete response,18 achieved a conform partial response;the total response rate is 87. 1%,toxicity was mainly related to myelosuppression. other toxicity was relatively lighter. conclusion:gemcitabine and cisplatin with radiotherapy represents a wel -tolera-ted active regimen for patients with squamous cellcarcinoma of the nasopharynx.