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目的：研究食管癌中Ｐ－糖蛋白表达的意义。方法：采用免疫组化方法检测５２例食管癌、９例鳞状上皮不典型增生及２６例正常食管组织中Ｐ－糖蛋白的表达。结果：６０％的食管癌、３３％的不典型增生及１２％正常食管组织中均有阳性表达。食管癌中Ｐ－糖蛋白表达与组织类型相关。结论：Ｐ－糖蛋白的表达参与了食管癌天然性耐药的产生，可作为指导临床化疗的参考指标
Objective: To study the significance of P-glycoprotein expression in esophageal cancer. Methods: Immunohistochemistry was used to detect the expression of P-glycoprotein in 52 cases of esophageal cancer, 9 cases of squamous epithelial dysplasia and 26 cases of normal esophageal tissues. Results: Positive expression was found in 60% of esophageal cancers, 33% of dysplasia, and 12% of normal esophageal tissues. P-glycoprotein expression in esophageal cancer is associated with tissue type. Conclusion: The expression of P-glycoprotein is involved in the development of natural resistance to esophageal cancer and can be used as a reference for clinical chemotherapy.