目的探讨老年脑卒中后抑郁症 (PSD)对神经功能缺损 (ANFD)、日常生活活动能力 (ADL)恢复的影响。方法按 CCMD－Ⅱ－ R的抑郁诊断标准将 172例老年脑卒中病人分为抑郁组、非抑郁组进行研究。结果 PSD组与非 PSD组的 ANFD和 ADL无显著差异 (P >0.05)，而 PSD组抑郁程度与 ANFD呈显著正相关，与 ADL呈显著负相关 (P< 0.05)。 PDS组的临床疗效显著，低于非 PSD组；且抑郁程度越重，临床疗效越差。结论 PSD明显影响临床疗效，对 ANFD及 ADL的恢复均不利。因此要重视对 PSD的预防及诊治。 Objective To investigate the effect of post-stroke depression (PSD) on neurological deficit (ANFD) and daily living activity (ADL) recovery. Methods According to the diagnostic criteria of depression of CCMD-Ⅱ-R, 172 elderly stroke patients were divided into depression group and non-depression group. Results There was no significant difference in ANFD and ADL between PSD group and non - PSD group (P> 0.05). However, the level of depression in PSD group was positively correlated with ANFD and negatively correlated with ADL (P <0.05). The clinical efficacy of PDS group was significantly lower than that of non-PSD group; and the more severe depression, the poorer clinical efficacy. Conclusion The clinical effect of PSD is obviously affected, which is unfavorable to the recovery of ANFD and ADL. Therefore, we should pay attention to the prevention and treatment of PSD.