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[目的] 探讨影响老年弥漫大B细胞淋巴瘤(DLBCL)患者的预后相关因素.[方法] 通过分析2009年1月至2014年12月本院血液科收治的70例老年DLBCL患者的性别、年龄、Ann-Arbor分期、B症状、体能状态ECOG评分、血清乳酸脱氢酶(LDH)、国际预后评分指数(IPI)、骨髓浸润等临床资料,探讨上述指标与预后的相关性,并比较R-CHOP与CHOP两种方案患者的生存情况.[结果] 70例老年DLBCL患者的中位生存期41.67个月,2年OS 率69.2%.单因素分析显示:年龄、Ann Arbor分期、ECOG 评分、IPI评分、治疗前LDH值、骨髓浸润、治疗方案均与预后有关(P<0.05);COX回归多因素分析表明:ECOG 评分、IPI评分、骨髓浸润、化疗方案是影响老年DLBCL患者预后的独立危险因素(P<0.01).[结论] ECOG 评分、IPI评分、骨髓浸润、化疗方案是影响老年DLBCL患者预后的独立危险因素;R-CHOP方案较CHOP方案疗效好,能够改善患者生存.“,”[Objective]To discuss the prognosis-related factors of elderly patients with diffuse large B-cell lymphoma (DLBCL).[Methods]We retrospectively analyzed the clinical data from 70 cases of elderly patients with initial diffuse large B-cell lymphoma from January 2009 to December 2014.The parameters included gender, age, Ann-Arbor staging, B symptoms, ECOG score of performance status (ECOG-PS), serum level of lactate dehydrogenase (LDH), international prognostic index (IPI) and bone marrow invasion.We also compared the survival of patients who received CHOP chemotherapy and R-CHOP chemotherapy.The correlation between these indexes and prognosis was analyzed.[Results]The median survival of all 70 cases of elderly patients with DLBCL was 41.67 months and the OS rate of 2 years was 69.2%.Single factor analysis showed that age, Ann-Arbor staging, bone marrow involvement, ECOG score, IPI score, value of LDH before treatment and therapeutic regimen were all related with prognosis (P<0.05 or P<0.01).COX regression multiple-factor analysis indicated that ECOG score、IPI score、bone marrow invasion and chemotherapy were the independent factors for predicting the prognosis of the elderly patients with DLBCL (P<0.01).[Conclusion]ECOG score、IPI score、bone marrow invasion and chemotherapy were independent predictive and prognostic factors in elderly patients with DLBCL.R-CHOP chemotherapy has more advantages than CHOP chemotherapy in improving prognosis of elderly patients with DLBCL.