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干扰素(Interferon,IFN)是其诱生剂诱导有关生物细胞产生的一类高活性糖蛋白,根据抗原性不同可分为α、β、γ三型。近年来,应用基因工程技术制备重组IFN获得成功,克服了来源上的困难,从而大大推动了IFN基础及临床应用研究的进展。确实,IFN愈来愈表现出多种重要的生物学功能,其中对正常造血的调节,对白血病等恶性造血细胞分化与增殖的影响等吸引了众多的血液学及肿瘤学工作者。深入探讨IFN的作用机理,将有助于全面理解骨髓造血的调控过程,为恶性肿瘤的治疗开辟新途径.
Interferon (IFN) is a type of highly active glycoprotein that induces the production of relevant biological cells by an inducer, and can be classified into α, β, γ three types according to different antigenicity. In recent years, the application of genetic engineering technology to the production of recombinant IFN has been successful, overcoming difficulties in the source, thus greatly promoting the progress of IFN basic and clinical application research. Indeed, IFNs increasingly exhibit a variety of important biological functions, among which the regulation of normal hematopoiesis, the influence on the differentiation and proliferation of malignant hematopoietic cells such as leukemia, etc. have attracted numerous hematology and oncology workers. In-depth study of the mechanism of IFN will help to fully understand the regulation of bone marrow hematopoiesis, open up new ways for the treatment of malignant tumors.