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目的 对比分析抑郁症患者采取草酸艾司西酞普兰与盐酸帕罗西汀治疗效果?方法本次试验120例抑郁症患者均为本院接收治疗，时间为2018年5月至2019年4月，根据入院单号?双号分为两组，对照组(n=60)与研究组(n=60)分别开展盐酸帕罗西汀与草酸艾司西酞普兰治疗方案，统计各组临床治疗效果及不良反应发生率，并评估患者治疗前后抑郁评分?结果 在治疗总有效率及不良反应发生率方面，对照组分别是81.67%和15.00%，研究组分别是95.00%和3.33%，研究组相比于对照组更优(P<0.05);在HAMD 评分“,”Objective To compare the therapeutic effects of escitalopram oxalate and paroxetine hydrochloride in patients with depression.Methods One hundred and twenty patients with depression were admitted to our hospital from May 2018 to April 2019.They were divided into two groups according to the admission order number and double number.The control group (n=60) and the study group (n=60) were given paroxetine hydrochloride and escitalopram oxalate，respectively.Depression scores were assessed before and after treatment.Results The total effective rate and the incidence of adverse reactions were 81.67% and 15.00% in the control group and 95.00% and 3.33% in the study group，respectively.The study group was better than the control group (P0.05).After treatment，the study group was lower than the control group (P0.05).After treatment，the study group was better than the control group (P<0.05).Conclusion Escitalopram oxalate is better than paroxetine hydrochloride in the treatment of depression，which can not only relieve the symptoms of depression，but also promote the improvement of the treatment effect，and has high safety，which provides a guarantee for the treatment of patients，and can be more clinically applied.