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目的 :探讨血浆内皮素 (ET) ,降钙素 (CGRP)含量与高原慢性萎缩性胃炎 (CAG)的关系。方法 :选取工作生活环境均在海拔 30 0 0m以上的CAG患者 12 0例为CAG组 ,慢性浅表性胃炎(CSG) 32例为CSG组 ,健康体检查者 32例为对照组 ,用放免法检测空腹静脉血ET、CGRP含量。结果 :①高原CAG组血浆ET水平明显高于高原CSG组和对照组 (P <0 .0 1) ,CGRP水平明显低于CSG组和对照组 (P <0 .0 1) ;高原CSG组血浆ET水平高于对照组 ,CGRP水平低于对照组 ,但与对照组比较差别无统计学意义 (P >0 .0 5 ) ;②轻、重度高原CAG患者之间血浆ET含量差别有统计学意义 (P <0 .0 5 ) ;血浆CGRP含量除中、重度高原CAG间差别无统计学意义 (P >0 .0 5 )外 ,其余组间的差别有统计学意义 (P <0 .0 5 ) ;③高原CAG患者血浆ET与CGRP含量呈负相关 (r =- 0 .2 14 ,P =0 .0 2 )。结论 :ET、CGRP参与高原CAG的病理生理过程 ,其含量的变化与萎缩程度有关 ,也是高原人易发高原CAG的重要因素之一
Objective: To investigate the relationship between plasma endothelin (ET), calcitonin (CGRP) and altitude atrophic gastritis (CAG). Methods: One hundred and twenty CAG patients with working and living environment above 30 000 m altitude were selected as CAG group, 32 patients with chronic superficial gastritis (CSG) as CSG group and 32 healthy controls as control group. Detection of fasting venous blood ET, CGRP content. Results: ① Plasma ET level in plateau CAG group was significantly higher than that in plateau CSG group and control group (P <0.01), CGRP level was significantly lower than that in CSG group and control group (P <0.01) ET level was higher than that of the control group, while CGRP level was lower than that of the control group, but there was no significant difference compared with the control group (P> 0.05); ② There was significant difference in plasma ET content between mild and severe plateau CAG patients (P <0.05). There was no significant difference in plasma CGRP levels between the medium and high altitude CAG (P> 0.05) (P <0.05) ); ③ Plasma ET and CGRP levels were negatively correlated in patients with plateau CAG (r = - 0.22, P = .0 2). Conclusion: ET and CGRP are involved in the pathophysiological process of plateau CAG. The changes of their contents are related to the degree of atrophy and are also one of the important factors of plateau CAG