论文部分内容阅读
目的:探讨脑梗死患者血清同型半胱氨酸(Hcy)和超敏C反应蛋白(hs-CRP)含量的变化及其与脑梗死相关危险因素的关系。方法:选择收治发病时间≤24 h且临床资料完整的脑梗死患者47例为脑梗死组,另选择同时期于我院行健康体检者30例作为对照组,测定两组血清Hcy和hs-CRP的含量,并分析两者与脑梗死相关危险因素的关系。结果:脑梗死组血清Hcy和hs-CRP水平均明显高于对照组(P<0.01)。脑梗死患者血清Hcy与SBP、DBP、FBS、血小板计数、TC、TG、LDL-C、颈内动脉斑块检出率、NIHSS评分呈正相关(P<0.05),与HDL-C水平呈负相关(P<0.05),而与BMI和WHR无明显相关性。血清hs-CRP与SBP、DBP、BMI、WHR、FBS、血小板计数、TC、TG、LDL-C、颈内动脉斑块检出率、NIHSS评分均呈正相关(P<0.05),与HDL-C水平呈负相关(P<0.05)。结论:血清Hcy、hs-CRP水平增高与脑梗死的发生、发展和预后密切相关,且可能是脑梗死发生的独立危险因素。
Objective: To investigate the changes of serum homocysteine (Hcy) and hypersensitive C-reactive protein (hs-CRP) in patients with cerebral infarction and their relationship with risk factors related to cerebral infarction. Methods: Forty-seven patients with cerebral infarction whose morbidity time was less than 24 h and whose clinical data were complete were selected as cerebral infarction group. Another 30 healthy volunteers in our hospital were selected as control group at the same time. Hcy and hs-CRP , And analyze the relationship between them and the risk factors related to cerebral infarction. Results: The levels of serum Hcy and hs-CRP in cerebral infarction group were significantly higher than those in control group (P <0.01). Serum Hcy in patients with cerebral infarction was positively correlated with SBP, DBP, FBS, platelet count, TC, TG, LDL-C, carotid artery plaque detection rate and NIHSS score (P <0.05) (P <0.05), but not with BMI and WHR. Serum hs-CRP was positively correlated with SBP, DBP, BMI, WHR, FBS, platelet count, TC, TG and LDL-C, carotid artery plaque detection rate and NIHSS score Level was negatively correlated (P <0.05). Conclusion: The increase of serum Hcy and hs-CRP levels is closely related to the occurrence, development and prognosis of cerebral infarction, and may be an independent risk factor for cerebral infarction.