很多流行病学资料表明:环境因素特别是食物因素与癌的发生有密切关系。在食物因素中,除污染毒素外,蛋白质,微量元素及去脂物质含量特别重要。本文拟就胆硷(一种主要的去脂物质)与肝癌关系的实验研究进展作一综述。 一、研究简史 自1932年Best发现胆硷有去脂作用,用胆硷缺乏食物喂饲小鼠可引起肝脏脂肪化, Many epidemiological data indicate that environmental factors, especially food factors, are closely related to the occurrence of cancer. Among food factors, protein, trace elements and fat-removing substances are particularly important in addition to contaminating toxins. This article aims to review the experimental research progress of the relationship between cholestasis, a major fat-removing substance, and liver cancer. First, a brief history of the study Since the discovery in 1932 that the cholestasis has a fat-free effect, feeding a mouse with a lack of cholestergic food can cause liver fat,