论文部分内容阅读
尾加压素Ⅱ(UrotensinⅡ,UⅡ)最初是从硬骨鱼的尾部下垂体中分离得到的一种类似于生长抑素的环肽。各种动物来源的UⅡ均由11～15个氨基酸组成,活性中心均为CFWKYC6个氨基酸组成的环状结构。1998年Coulouarn等在人体组织中发现UⅡ,并认为其是一种强烈的血管收缩剂。1999年,Ames等最先证明了孤儿受体GPR14是UⅡ的特异性受体,国际药理联合会(IUPHAR)将其命名为UT。UT是一种G蛋白偶联受体,至今尚未发现其受体亚型。最近又发现了一种尾加压素Ⅱ相关肽(urotensin related-peptide,URP),它在UⅡ的活性结构两端各连接一个氨基酸残基,并具有UⅡ相似的作用。很多学者对以上三种激素进行了大量研究,现研究证明其可能与肺脏疾病有关。本文对其作一综述。
Urotensin II (UII) was originally a somatostatin-like cyclic peptide isolated from the tail pituitary of teleost fish. UII from various animal sources are composed of 11 to 15 amino acids, the active center are CFWKYC6 amino acid ring structure. In 1998 Coulouarn et al found U II in human tissues and considered it to be a strong vasoconstrictor. In 1999, Ames et al. First demonstrated that orphan receptor GPR14 is a specific receptor for UII, and the International Union of Pharmacologicals (IUPHAR) named it UT. UT is a G-protein coupled receptor, so far no receptor subtypes have been found. Recently, a urotensin related-peptide (URP) has been found, which has a UⅡ-like function by connecting two amino acid residues at both ends of the active structure of UⅡ. Many scholars have done a lot of research on these three hormones, and research shows that they may be related to lung diseases. This article reviews it.