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目的:研究前列腺特异抗原(PSA)是否可作为女性高雄激素症诊断的标志。方法:正常对照组50例,高雄激素症组45例,分别测定血清PSA、睾酮(T)、性激素结合球蛋白(SHBG)、硫酸脱氢表雄酮(DHEA-S)水平,对两组测定值进行统计学分析。结果:正常对照组血清PSA值为(3.56±0.44)pg/ml,高雄激素症组为(9.72±1.39)pg/ml,两组有显著性差异(P<0.01)。血清PSA值与T、DHEA-S值之间呈弱的正相关关系(分别为r=0.226,P<0.05;r=0.255,P<0.05);与SHBG值之间有弱负相关关系(r=-0.228,P<0.05)。结论:PSA可作为女性雄激素增高的标志物而在临床应用。
Objective: To study whether prostate specific antigen (PSA) can be used as a marker for the diagnosis of hyperandrogenism in women. Methods: 50 cases of normal control group and 45 cases of hyperandrogenism group were measured serum PSA, testosterone (T), sex hormone binding globulin (SHBG), DHEA-S level, Values for statistical analysis. Results: The serum PSA level was (3.56 ± 0.44) pg / ml in normal control group and (9.72 ± 1.39) pg / ml in hyperandrogenism group, with significant difference between the two groups (P <0.01). There was a weak positive correlation between serum PSA and T and DHEA-S (r = 0.226, P <0.05, r = 0.255, P < = -0.228, P <0.05). Conclusion: PSA can be used as a marker of female androgen elevation in clinical practice.