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新近Guillemin等和Vale等分别报道了两例具有肢端肥大症体征的胰腺瘤患者。他们从胰瘤中各自发现了有44和40个氨基酸组成的能使GH释放的多肽,称之为人胰促生长激素释放因子(hpGRF)。44个氨基酸的序列为:酪-丙-天冬-丙-异亮-苯丙-苏-天冬酰-丝-酪-精-赖-缬-亮-甘-谷氨酰-亮-丝-丙-精-赖-亮-亮-谷-天冬-异亮-甲硫-丝-精-谷-谷-甘-谷-丝-天冬酰-谷-谷-精-甘-丙-精-丙-精-亮-NH_2。Vale报道的GRF含有40个氨基酸,其结构与Guillemin报道的大分子N-端序列相同。该多肽无论在试管内或在整体内均能特异地促使GH释放,但对脑垂体的其它激素,如催乳素、促性腺激素、ACTH和促甲状腺素均无释放效应。
Recently, Guillemin et al. And Vale et al. Reported two cases of pancreatic adenomas with signs of acromegaly. They each found from the pancreatic tumor 44 and 40 amino acids can release GH peptide, called human pancreatic stimulating hormone growth factor releasing factor (hpGRF). The sequence of 44 amino acids is as follows: - Asp - Asp - Asp - Asp - Styrene - Asp - Asp - Aspartame - Aspartame - Aspartame - Aspartame - Aspartame - Aspartame - Aspartame - Aspartame - Aspartame - Aspartame - Aspartame - Aspartame - Aspartame - Aspartame - - C - Jing - bright -NH_2. The GRF reported by Vale contains 40 amino acids and has the same structure as the N-terminal sequence of the macromolecule reported by Guillemin. The polypeptide can specifically promote GH release both in vitro and in vivo, but has no release effect on other pituitary hormones such as prolactin, gonadotropin, ACTH and thyrotropin.