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DNA旋转酶编码基因(gyrA和gyrB)和拓扑异构酶编码基因(parC和parE)的染色体突变、多重药物外排泵AcrAB表达水平升高以及存在质粒介导acc(6′)-Ib-cr和各种qnr基因等耐药机制均可导致氟喹诺酮类药物对大肠埃希菌的MIC升高。已有报道环丙沙星、加替沙星、左氧氟沙星和诺氟沙星对?
Chromosome mutation of DNA gyrase encoding genes (gyrA and gyrB) and topoisomerase encoding genes (parC and parE), increase of AcrAB expression in multidrug efflux pump and presence of plasmid-mediated acc (6 ’) - Ib-cr And various qnr gene resistance mechanisms can lead to fluoroquinolones MIC of Escherichia coli increased. Ciprofloxacin, gatifloxacin, levofloxacin and norfloxacin have been reported.