免疫RNA的发现用肠炎沙门氏菌感染小鼠,可引起全身感染,网状内皮系统肉芽肿形成,且最终死于感染。以肠炎沙门氏菌活疫苗高度免疫的小鼠,则能耐受肠炎沙门氏菌116-54毒性株1,000个最小致死量(MLD)的静脉攻击。此攻击后存活鼠可完全耐受同一细菌1万个MLD的再攻击。由免疫小鼠腹腔、肝脏或皮下组织中获得的单核吞噬细胞能耐受存在 Immunodetection RNA in mice infected with Salmonella enteritidis can cause systemic infections, reticuloendothelial granulation, and eventually death from infection. Mice immunized with the live Salmonella enteritidis vaccine were able to tolerate 1,000 minimal lethal dose (MLD) intravenous challenge with Salmonella enteritidis 116-54 virulent strains. This post-challenge survivor fully resisted the re-attack of 10,000 MLDs of the same bacterium. Mononuclear phagocytes obtained from the peritoneal, hepatic or subcutaneous tissues of immunized mice tolerated the presence