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以离子液体1-丁基-3-甲基咪唑双三氟甲基磺酰亚胺鎓盐([Bmim]Tf2N)为萃取剂,采用微波辅助萃取法(MAE)对川芎中的洋川芎内酯I和H及藁本内酯的萃取进行了研究.考察了温度、时间、相比和原药粒径等因素对萃取效果的影响,比较了MAE和传统溶剂回流萃取法(SRE)的萃取率,并对萃取后的固体做了SEM研究.结果表明,萃取温度对萃取率影响显著,在180℃下对3种内酯类化合物均体现出良好的萃取效率;萃取在1min内达到平衡;固/液比为1/30～1/5g/mL和原药粒径0.096～0.25mm范围内对萃取效率没有显著影响;与SRE相比,MAE耗时短、效率高,对提高藁本内酯萃取效率尤为显著,提高达46%;由样品表面结构变化可见,MAE萃取的样品结构被破坏,有助于活性组分释放、提高萃取率.
The ionic liquid 1-butyl-3-methylimidazolium bistrifluoromethylsulfonyl imide ([Bmim] Tf2N) was used as the extractant, and microwave assisted extraction (MAE) I and H and ligustilide extraction were studied.The effects of temperature, time, the ratio of the original particle size and other factors on the extraction efficiency were investigated, the extraction rate of MAE and traditional solvent reflux extraction (SRE) , And the SEM was carried out on the extracted solid.The results showed that the extraction temperature had a significant effect on the extraction yield and the three lactone compounds showed good extraction efficiency at 180 ℃. / Liquid ratio of 1/30 ~ 1 / 5g / mL and the original drug particle size 0.096 ~ 0.25mm range of extraction efficiency had no significant effect; compared with SRE, MAE time-consuming, high efficiency, to improve ligustilide Extraction efficiency is particularly significant, increased up to 46%; from the sample surface structure changes can be seen MAE sample structure is damaged, contributing to the release of the active ingredient to improve the extraction rate.