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联苯双酯(简称BDD)是根据中药五味子的有效成分之一丙素的合成中间体,经筛选而得到的。BDD的药理作用是能降低血清丙谷酶(SGPT)的活性,能促进部分切除肝脏的小鼠肝脏的再生,加速肝脏对戊巴比妥的代谢,具有保肝解毒作用。由于BDD的脂溶性强,较易于通过血脑屏障进入大脑产生中枢抑制作用,长期服用出现头晕、嗜睡等症状。另外,BDD的生物利用度仅为30％～39％,为减少BDD的中枢抑制作用,提高生物利用度,考虑降低它的亲脂性。首先,将BDD水解成钠盐,结果它的
Bifendate (referred to as BDD) is based on the active ingredient of Schisandra one of the synthetic intermediates propionate, obtained by screening. The pharmacological action of BDD is to reduce the activity of serum glutathione peroxidase (SGPT), promote the liver regeneration of partially resected liver, accelerate the metabolism of pentobarbital in the liver, and protect liver from detoxification. BDD lipid-soluble strong, easier to enter the brain through the blood-brain barrier to produce central inhibitory effect, long-term use appear dizzy, lethargy and other symptoms. In addition, BDD bioavailability of only 30% to 39%, in order to reduce the central inhibition of BDD, improve bioavailability, consider reducing its lipophilicity. First, BDD is hydrolyzed to sodium salt, which results in it