1980年首次报告内皮依赖的血管扩张作用,目前有越来越多的证据表明,血管内皮单位起着一种血管平滑肌张力调节系统的作用。当受到作用于血管的药物刺激时,如乙酰胆碱或舒缓激肽,内皮细胞释放内皮衍生舒张因子,这种因子相当于或近似于氧化氮。培养内皮细胞也可产生和分泌血管收缩因子,例如从猪和人类细胞分离的21肽的内皮细胞素(endothelin)。现在本作者从尿毒症患者测定 The first report of endothelium-dependent vasodilatation in 1980, there is more and more evidence that vascular endothelial units play a role in vascular smooth muscle tone regulating system. Endothelial-derived relaxing factors are released by endothelial cells when stimulated with drugs acting on the bloodstream, such as acetylcholine or bradykinin, which is equivalent to or approximates nitric oxide. Cultured endothelial cells may also produce and secrete vasoconstrictors, such as the endothelin of the 21 peptide isolated from porcine and human cells. Now the author measured from patients with uremia