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利用特异性单克隆抗体,采用免疫催化方法,对70例肝癌(原发性肝癌49例,转移性肝癌21例)病人,进行血清大分子硷性磷酸酶(HMAP)同工酶活力与甲胎蛋白(AFP)定量的测定,且与24例胆囊炎、19例急性肝炎及104例正常人的检测做对比分析。结果显示:70例肝癌病人的血清HMAP阳性率为96%,其中原发性肝癌的阳性率96%,转移性肝癌的阳性率95%。与AFP定量测定比较,HMAP诊断肝癌,尤其转移性肝癌,具有更高的敏感性及特异性。
Using monoclonal antibodies and immunocatalytic methods, serum macromolecule alkaline phosphatase (HMAP) isoenzyme activity and alpha-fetoprotein were detected in 70 cases of hepatocellular carcinoma (49 cases of primary liver cancer and 21 cases of metastatic hepatocellular carcinoma). Quantitative determination of protein (AFP) was performed and compared with 24 cases of cholecystitis, 19 cases of acute hepatitis and 104 cases of normal persons. The results showed that the serum HMAP positive rate was 96% in 70 patients with liver cancer, of which the positive rate of primary liver cancer was 96%, and the positive rate of metastatic liver cancer was 95%. Compared with the quantitative determination of AFP, HMAP has higher sensitivity and specificity in the diagnosis of liver cancer, especially metastatic liver cancer.