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目的探讨分析甲胎球蛋白和癌胚抗原联合应用在检测和诊断肝癌中的临床价值。方法按照知情同意原则分别选取我院2010年7月至2012年9月收治的73例原发性肝癌患者和同期的73例健康的体检者,分别组成观察组和对照组。对两组中的所有患者分别进行甲胎球蛋白和癌胚抗原联合检测,并准确记录,对结果进行分析。结果观察组中患者的两种癌症标志物相较于对照组在各级含量比较中均具有显著差异(P<0.05);当将两个指标联合作为肝癌诊断指标时,如选择甲胎球蛋白超过25μg/L和癌胚抗原超过5μg/L为肝癌阳性,则原发性肝癌的检出率分别为80.82%(59/73)和74.58%(44/73)。若以甲胎球蛋白超过500μg/L且癌胚抗原超过5μg/L为肝癌阳性,则患者的肝癌检出率为74.58%,此时肝癌检测的特异性为74.58%。结论甲胎球蛋白和癌胚抗原结合是值得广泛推广的诊断标准。
Objective To investigate the clinical value of the combination of mevaloglobin and carcinoembryonic antigen in the detection and diagnosis of liver cancer. Methods According to the principle of informed consent, 73 cases of primary hepatocellular carcinoma patients and 73 healthy subjects were selected from July 2010 to September 2012 in our hospital respectively to form the observation group and the control group. All patients in both groups were tested for the presence of both melatonin and carcinoembryonic antigen, and the results were accurately recorded and analyzed. Results There were significant differences in the levels of two cancer markers in the observation group compared with the control group (P <0.05). When the combination of the two indicators as a diagnostic indicator of liver cancer, such as the choice of metmylobacin The detection rates of primary hepatocellular carcinoma were 80.82% (59/73) and 74.58% (44/73), respectively, when more than 25μg / L carcinoembryonic antigen and 5μg / L carcinoembryonic antigen were positive for liver cancer. The detection rate of hepatocellular carcinoma was 74.58% when the quantity of melanocyte globulin exceeded 500μg / L and carcinoembryonic antigen was more than 5μg / L. The specificity of detecting hepatocellular carcinoma was 74.58%. Conclusion The combination of alpha-fetoprotein and carcinoembryonic antigen is a widely used diagnostic criteria.