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目的总结创伤性脑外伤(traumatic brain injury,TBI)对骨折愈合影响机制研究的进展。方法广泛查阅国内外有关TBI对骨折愈合影响的文献,并进行总结分析。结果 TBI影响骨折愈合机制复杂,研究方向可大致分为骨折愈合过程中血管生成及骨再生的调节,以及脑外伤后神经肽及相关激素反应后的局部和全身变化。结论 TBI对骨折愈合起促进作用,其确切作用机制有待进一步研究。
Objective To summarize the research progress on the mechanism of fracture healing induced by traumatic brain injury (TBI). Methods Extensive access to the literature on the impact of TBI on fracture healing at home and abroad, and a summary analysis. Results TBI had a complex mechanism of fracture healing. The research directions could be divided into the regulation of angiogenesis and bone regeneration during fracture healing, as well as the local and systemic changes after neuropeptide and related hormonal reactions after traumatic brain injury. Conclusion TBI can promote the healing of fractures. The exact mechanism remains to be further studied.