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目的探讨丹红联合长春西汀治疗脑梗死的疗效及其作用机制。方法将238例发病24 h内的大面积脑梗死患者随机分为对照组及联合治疗组,对照组口服肠溶拜阿司匹林+阿托伐他汀并静脉滴注依达拉奉+甘露醇注射液作为基础治疗;联合治疗组在此基础治疗上静脉滴注丹红+长春西汀注射液;记录治疗前后脑电图(EEG)、局部脑血流(r CBF)并测定一氧化氮(NO)、丙二醛(MDA)含量及一氧化氮合成酶(NOS)、超氧化物歧化酶(SOD)活性。结果治疗前两组EEG、r CBF和NO、MDA含量及NOS、SOD活性间差异均无统计学意义(P>0.05);而治疗后联合治疗组r CBF、EEG和NO含量及NOS、SOD活性高于对照组,而MDA含量低于对照组(P<0.05)。结论在治疗大面积脑梗死时,丹红联合长春西汀有药物协同作用,疗效可靠,值得推广联合用药。
Objective To investigate the efficacy and mechanism of Danhong combined with vinpocetine in the treatment of cerebral infarction. Methods 238 cases of large-area cerebral infarction within 24 hours of onset were randomly divided into the control group and the combination therapy group. The control group was treated with oral enteric-coated aspirin plus atorvastatin and edaravone plus mannitol injection The combination therapy group received intravenous infusion of Danhong + Vinpocetine injection on the basis of this treatment. EEG and r CBF were recorded before and after treatment, and the levels of nitric oxide (NO), nitric oxide Malondialdehyde (MDA) content and the activity of nitric oxide synthase (NOS) and superoxide dismutase (SOD). Results There was no significant difference in the levels of EEG, r CBF, NO, MDA and the activities of NOS and SOD between the two groups before treatment (P> 0.05), while the levels of r CBF, EEG and NO and the activities of NOS and SOD in the combined treatment group Higher than the control group, while the MDA content was lower than the control group (P <0.05). Conclusion Danhong combined with vinpocetine has a synergistic effect in the treatment of large-area cerebral infarction, which has reliable curative effect and is worth promoting combination therapy.