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目的观察2型糖尿病(T2DM)患者应用胰岛素联合阿卡波糖治疗后晚夜间胰岛素用量的变化,以及夜间低血糖的改善情况。方法采用动态血糖监测系统(CGMS)对胰岛素强化治疗中发生夜间低血糖的T2DM患者晚餐时应用阿卡波糖前后进行血糖监测,比较阿卡波糖治疗前后晚夜间胰岛素用量及夜间低血糖变化。结果 (1)联合阿卡波糖治疗后晚夜间胰岛素用量显著下降(P<0.05)。(2)联合阿卡波糖治疗明显减少夜间低血糖的次数,降低夜间低血糖指数(P均<0.05)。结论晚餐中加用阿卡波糖可减少晚夜间胰岛素用量,可延长晚餐消化吸收时间,避免夜间低血糖。
Objective To observe the changes of late night insulin dosage and insulin nocturnal hypoglycemia in patients with type 2 diabetes mellitus (T2DM) treated with insulin combined with acarbose. Methods Blood glucose was measured before and after the application of acarbose at dinner for T2DM patients with nocturnal hypoglycemia during intensive insulin therapy by dynamic glucose monitoring system (CGMS). The nighttime insulin dosage and nocturnal hypoglycemia after acarbose treatment were compared. Results (1) After the combination of acarbose treatment of late night insulin dosage decreased significantly (P <0.05). (2) Combination of acarbose treatment significantly reduced the number of nocturnal hypoglycemia and nighttime hypoglycemia index (all P <0.05). Conclusions Adding Acarbose to dinner can reduce nighttime insulin dosage, prolong dinner digestion and absorption time, and avoid nighttime hypoglycemia.