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目的探讨老年晚期非小细胞肺癌(NSCLC)的临床特点及预后因素。方法回顾性分析2005年1月至2006年12月收治的184例老年晚期NSCLC患者的临床资料,随访生存情况,分析性别、吸烟状况、Karnofsky评分(KPS)、TNM分期、病理类型、简化合并症评分(simplified comorbidi-ty score,SCS)和治疗方式等因素对老年晚期NSCLC患者生存期的影响。结果全组患者中位年龄73岁,确诊肺癌后5年生存率为11.4%。单因素分析显示,KPS、TNM分期、SCS、手术、化疗和(或)靶向治疗与预后相关。Cox多因素分析显示,KPS<70分、SCS>9分、未行化疗和(或)靶向治疗是影响老年晚期NSCLC患者的独立预后不良因素。结论 KPS、合并症和治疗方式等多种因素影响老年晚期NSCLC患者的预后生存,老年肺癌患者多伴有合并症,重视并积极控制合并症,有助于改善预后,延长生存时间。
Objective To investigate the clinical features and prognostic factors of advanced non-small cell lung cancer (NSCLC). Methods The clinical data of 184 elderly patients with advanced NSCLC who were admitted from January 2005 to December 2006 were retrospectively analyzed. Survival status, sex, smoking status, Karnofsky score (KPS), TNM stage, pathological type, (Simplified comorbidi-ty score, SCS) and treatment and other factors on the survival of elderly patients with advanced stage of non-small cell lung cancer. Results The median age of all patients was 73 years. The 5-year survival rate after diagnosis of lung cancer was 11.4%. Univariate analysis showed that KPS, TNM staging, SCS, surgery, chemotherapy and / or targeted therapy were associated with prognosis. Cox multivariate analysis showed that KPS <70, SCS> 9, and no chemotherapy and / or targeted therapy were independent prognostic factors in elderly patients with advanced NSCLC. Conclusion Various factors such as KPS, comorbidity and treatment affect the prognosis of elderly patients with advanced non-small cell lung cancer (NSCLC). Patients with lung cancer often have comorbidities, and pay more attention to and control the comorbidities, which can improve the prognosis and prolong the survival time.