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重组cDNA表达文库血清学分析(SEREX)方法是一种筛选疾病相关抗原的有效分析方法,其筛选鉴定的疾病抗原不仅可对疾病进行早期检测,还能作为免疫治疗的靶标。本综述从肿瘤和其它具有免疫原性的疾病方面介绍了SEREX技术的应用价值,在总结SEREX缺点的基础上提出了SEREX技术的改进方向。
Serological analysis of recombinant cDNA expression library (SEREX) is an effective method for screening disease-associated antigens. The screening of identified disease antigens can not only be used for early detection of diseases but also as a target of immunotherapy. This review presents the value of SEREX technology in terms of oncology and other immunogenic diseases. Based on the conclusion of the SEREX flaw, this paper presents the improvement direction of SEREX technology.