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纤维连接蛋白是一种具有广泛生物效应的高分子糖蛋白,在细胞的粘附、迁移、分化和增殖中起关键作用。近年来不断有研究表明纤维连接蛋白在急性冠状动脉综合征的发病机制中扮演了不可或缺的角色,具有一定的诊断和预测预后的意义。文章主要就纤维连接蛋白的结构、在血小板血栓形成中的作用及其与急性冠状动脉综合征的关系作一综述。
Fibronectin is a macromolecular glycoprotein with a wide range of biological effects and plays a key role in cell adhesion, migration, differentiation and proliferation. In recent years, continuous studies have shown that fibronectin play an indispensable role in the pathogenesis of acute coronary syndrome, and have certain significance in diagnosis and prognosis. The article mainly reviews the structure of fibronectin, its role in platelet thrombosis and its relationship with acute coronary syndrome.