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目的为解决治疗前后采样部位差异问题,用胃粘膜内注墨法标记了胃癌前病变,追踪观察叶酸的疗效。方法胃粘膜异型增生患者75例,在病灶周围粘膜内注入印度墨水。分为叶酸治疗组和一般胃病治疗药对照组,在标记病灶范围内活检随访检查。结果注墨后胃粘膜内呈现清晰可见的小黑点,存留时间18±9(14-29)月,无不良反应。叶酸组疗效为41.0%(18/39),对照疗效为38.9%(14/36),二者比较,P>0.05。结论本方法标记胃癌前病变易行、可靠、安全。叶酸治疗胃癌前病变效果与一般胃病治疗药无显著差异。
Objective To solve the problem of differences in sampling sites before and after treatment, label gastric precancerous lesions with gastric intramucosal instillation, and follow-up the efficacy of folic acid. Methods 75 patients with dysplasia of gastric mucosa were injected with Indian ink in the mucosa around the lesion. Divided into folic acid treatment group and general stomach treatment drug control group, biopsy follow-up inspection within the scope of marked lesions. Results After the ink injection, there was a clear and visible black spot in the gastric mucosa. The survival time was 18±9 (14-29) months, and there was no adverse reaction. The efficacy of folic acid group was 41.0% (18/39), and the control efficacy was 38.9% (14/36). The two were compared, P>0.05. Conclusion This method is an easy, reliable and safe method for marking precancerous lesions. The effect of folic acid in the treatment of gastric precancerous lesions was not significantly different from that of general stomach disorders.