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目的 :探讨多发性骨髓瘤 (MM)细胞免疫功能和 CD+ 38细胞的表达。方法 :采用免疫学方法检测了 2 5例 MM患者外周血 T-淋巴细胞亚群和 CD+ 38细胞的含量 ,同时检测了 18例正常献血员的细胞免疫功能和 CD+ 38细胞。结果 :MM患者 CD+ 3细胞、CD+ 4细胞、CD+ 4/ CD+ 8比值下降 ,CD+ 8细胞比值增高 (P均 <0 .0 5 ) ;MM患者外周血 CD+ 38细胞明显增多 ,并显著高于正常对照组 (P<0 .0 5 )。结论 :MM患者存在细胞免疫功能紊乱 ,并表现为外周血中 CD+ 38细胞显著增高 ,与诊断密切相关
Objective: To investigate the cellular immune function and the expression of CD + 38 cells in multiple myeloma (MM). Methods: T-lymphocyte subsets and CD + 38 cells in 25 patients with MM were detected by immunological method. The cellular immune function and CD + 38 cells in 18 normal blood donors were also tested. Results: The ratio of CD + 3 cells, CD + 4 cells and CD + 4 / CD + 8 in MM patients decreased and the ratio of CD + 8 cells increased (all P <0.05); CD + 38 cells in peripheral blood of MM patients increased significantly Control group (P <0.05). Conclusion: There is cellular immune dysfunction in patients with MM, and the expression of CD + 38 cells in peripheral blood is significantly higher, which is closely related to the diagnosis