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目的:以脱乙酰壳聚糖为药物载体,制备了对乙酰氨基酚壳聚糖微球,测定微球中对乙酰氨基酚的体外释放度。方法:采用乳化-化学交联法制备微球,分光光度法测定对乙酰氨基酚的含量。结果:对乙酰氨基酚壳聚糖微球的平均粒径为(27.8±1.2)μm,包封率为35.8%,载药量为9.0%。结论:以壳聚糖为载体,采用乳化-化学交联法制备对乙酰氨基酚缓释微球,体外药物释放结果显示对乙酰氨基酚壳聚糖微球与普通片剂进行比较,微球的缓释效果良好。
OBJECTIVE: Acetaminophen chitosan microspheres were prepared using chitosan as drug carrier and the in vitro release of acetaminophen was determined. Methods: Microspheres were prepared by emulsion - chemical cross - linking method and the content of acetaminophen was determined by spectrophotometry. Results: The average particle size of paracetamol chitosan microspheres was (27.8 ± 1.2) μm, the encapsulation efficiency was 35.8% and the drug loading was 9.0%. CONCLUSION: Acetaminophen sustained-release microspheres were prepared by emulsion-chemical cross-linking method using chitosan as carrier. The in vitro drug release results showed that acetaminophen chitosan microspheres were compared with conventional tablets. Slow release effect is good.