论文部分内容阅读
目的:探讨HIV相关型Kaposi肉瘤的临床特点。方法:回顾性分析4例资料完整的HIV并发Kaposi肉瘤临床资料。结果:患者均为汉族人,皮损累及面部及口腔的3例,伴有双上肢皮损1例,肛周出现皮损1例。胸部CT均有微结节或弥漫性结节及毛玻璃影。皮损组织病理均诊断为Kaposi肉瘤,免疫组化结果:CD31(+),CD34(+),Ⅷ因子(+)3例,人疱疹病毒(HHV)-8(+)2例。CD4~+细胞数均低于1.2×10~8/L,平均0.495×10~8/L,HIV RNA均高于2.0×10~(10)拷贝/L,平均为5.77×10~(11)拷贝/L。结论:HIV相关型Kaposi肉瘤在汉族人中发病率极低,该病的发生有可能与CD4~+细胞数极低和病毒载量较高有关系。
Objective: To investigate the clinical features of HIV-related Kaposi’s sarcoma. Methods: The clinical data of 4 cases of Kaposi’s sarcoma were retrospectively analyzed. Results: All patients were Han nationality. There were 3 cases of skin lesions involving the face and mouth, 1 case of bilateral upper extremity skin lesions and 1 case of perianal lesions. Chest CT has nodules or diffuse nodules and ground glass shadow. The histopathology of lesions was diagnosed as Kaposi sarcoma. Immunohistochemistry results showed that there were 3 cases of CD31 (+), CD34 (+), Ⅷ factor (+) and 2 cases of human herpesvirus (HHV) -8 (+). The number of CD4 ~ + cells was lower than 1.2 × 10 ~ 8 / L, with an average of 0.495 × 10 ~ 8 / L and HIV RNA levels were higher than 2.0 × 10 ~ 10 copies / L with an average of 5.77 × 10 ~ Copy / L. Conclusion: The incidence of HIV-related Kaposi’s sarcoma is very low in Han people. The occurrence of this disease may be related to the extremely low CD4 ~ + cell count and high viral load.