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目的:观察大鼠连续静脉/腹腔交替注射刺五加注射液产生的毒性反应与靶器官损害的可逆性。方法:通过血液学、血液生物化学和病理组织学检查,观察注射刺五加注射液对大鼠的毒性反应及程度。结果:连续静脉/腹腔交替注射刺五加注射液4周,动物全部存活,高、低剂量组动物未见明显毒性反应,停药后各剂量组均未见迟缓性毒性发生。结论:刺五加注射液连续静脉/腹腔交替注射对大鼠体重增长率、各主要器官脏器系数、血细胞和血液生化指标均无显著影响,病理组织学检查亦未见毒性病理改变,停药后2周亦未见延迟毒性,即刺五加注射液对大鼠无明显毒性。
Objective: To observe the reversibility of toxicity and target organ damage induced by continuous intravenous / intraperitoneal injection of acanthopanax senticosus injection. Methods: Hematology, blood biochemistry and histopathological examination were used to observe the toxic effects and the degree of acanthopanax senticosus injection on rats. Results: The continuous intravenous / intraperitoneal injection of Acanthopanax senticosus injection for 4 weeks, all the animals survived, high and low dose group of animals showed no significant toxicity, no delay after each dose dose of the group were delayed toxicity. CONCLUSION: Continuous injection of Acanthopanax senticosus by continuous intravenous / intraperitoneal injection has no significant effect on the rate of weight gain, organ coefficient of major organs, blood cells and blood biochemical parameters, and pathological examination also showed no toxic and pathological changes, withdrawal No delay after 2 weeks of toxicity, that Acanthopanax injection was no significant toxicity in rats.