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目的探讨利奈唑胺引起的血液系统不良反应的特点,分析用药安全性。方法回顾性选择2015年1月~2016年1月在我院住院治疗的220例患者的临床资料,220例患者在住院期间均服用利奈唑胺。观察患者使用利奈唑胺的血液不良反应发生情况,分析患者的血液系统不良反应及停药情况,探讨不良反应发生率和患者用药时间的关系。结果 220例患者中,发生血液不良反应患者72例,导致停药患者13例;未发生血液不良反应患者148例。利奈唑胺发生血液不良反应患者中男性比例比女性高。70岁以上的老年人易发生利奈唑胺血液不良反应。发生血液不良反应患者的临床表现为血液系统受抑、血小板显著降低、血红蛋白显著降低和中性粒细胞显著降低,血液系统受抑是主要的血液不良反应临床表现;治疗时间越长,患者不良反应发生率越高。结论临床上使用利奈唑胺治疗会引起血液系统不良反应,医护人员在治疗护理中需要加强关注患者的治疗情况。出现不良反应的患者,医护人员应该对症下药,确保患者得到有效安全的治疗。
Objective To investigate the characteristics of lineal adverse reactions caused by linezolid and analyze the safety of the drugs. Methods The clinical data of 220 patients hospitalized in our hospital from January 2015 to January 2016 were retrospectively reviewed. All of the 220 patients received linezolid during hospitalization. Observe the adverse reactions of linezolid in patients with adverse reactions, analysis of patients with adverse reactions and withdrawal of the blood system to explore the incidence of adverse reactions and the relationship between the patient medication time. Results Among the 220 patients, 72 patients had adverse reactions of blood, leading to 13 patients stopping drug withdrawal and 148 patients without adverse reactions of blood. Linezolid patients with adverse reactions to blood in men than women. Older people over 70 years old prone to linezolid adverse blood reaction. The clinical manifestations of patients with adverse reactions of blood are the suppression of the blood system, the significant reduction of platelets, the significant reduction of hemoglobin and the significant decrease of neutrophils, and the suppression of the blood system as the main clinical manifestations of adverse reactions of blood. The longer the treatment time is, the more adverse reactions The higher the incidence. Conclusion The clinical use of linezolid treatment can cause adverse reactions in the blood system, and medical staff need to pay more attention to the treatment of patients. Adverse reactions in patients, health care workers should be the right medicine, to ensure that patients receive effective and safe treatment.