肿瘤干细胞的鉴定成功对肿瘤发生的观点产生了新的挑战。干细胞最大的特点是非对称性分裂从而实现自我更新,如果这一过程被扰乱则会发生肿瘤。肿瘤抑制基因hscrib、hdlg被认为在这一分子机制中调节命运决定子在子代细胞中的分配。细胞极性是上皮组织的一个标志性特点,极性丢失与上皮的恶性转化密切相关。研究表明hScrib、hDlg是维持正常上皮极性的关键因子,在多种上皮性恶性肿瘤的发生中可能起一定作用。 The successful identification of cancer stem cells presents a new challenge to the idea of ​​tumorigenesis. The biggest feature of stem cells is the asymmetric division in order to achieve self-renewal, if this process is disrupted tumor will occur. The tumor suppressor gene hscrib, hdlg is thought to regulate the distribution of fate determinants in progeny cells in this molecular mechanism. Cell polarity is a hallmark of epithelial tissue. The loss of polarity is closely related to the malignant transformation of the epithelium. Studies have shown that hScrib, hDlg is a key factor to maintain the normal epithelial polarity, which may play a role in the occurrence of a variety of epithelial malignancies.