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镇痛药一方面能减轻或消除疼痛,另一方面又能积极地保护中枢神经系统,使其免受严重的伤害性刺激,故在医学上具有重大意义。镇痛药的数目甚多,可是,真正合乎理想要求的(镇痛作用强大,副作用小,安全范围广及久用不引起成(疒引)性),到目前还没有。因此,各国药物化学家们及药理学家们积极寻找新镇痛药之努力,是可以理解的;并且在合并用药方面(以期增加疗效,减少副作用及消除成(疒引)性)亦作了很多工作。兹就镇痛药物研究方法,新镇痛药及镇痛药合并用药等方面,作一简单综述。
Analgesics on the one hand can reduce or eliminate pain, on the other hand can actively protect the central nervous system, to avoid serious noxious stimulation, it is of great medical significance. The number of analgesics is very large, however, so far there is really no satisfactory (analgesic effect, small side effects, wide range of safety and long-term use). Therefore, it is understandable that drug chemists and pharmacologists in various countries are actively seeking new analgesics; and in the case of combination therapy (with the aim of increasing the curative effect, reducing the side effects and eliminating the inducement) lots of work. Here is a brief review of the analgesic drug research methods, new analgesics and analgesics combined with medication.