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对１９９０年招收的一组棉纺厂新工人１２９例（失访１９例，实际调查１１０例）分别于暴露前，暴露１０周及１年时进行了随访，研究棉尘接触与症状发生、肺功能改变及气道反应性的变化，及与特异体质等因素的关系。结果：班后ＦＥＶ１的下降幅度在１０周及１年时均较小，棉花抗原皮试阳性者稍大于阴性者。气道反应性在１０周时增强，１年时仍保持在较高水平，皮试阳性者增强尤为显著。咳痰及胸部紧束感等症状随暴露时间延长逐渐增多，而干咳和鼻腔刺激症状等在１年时比１０周有所减少。提示呼吸道炎症反应随棉尘暴露时间延长逐渐加重，棉花抗原皮试阳性者反应更重。
A total of 129 new cotton mill workers recruited in 1990 (19 lost and 110 actual) were followed up before, 10 and 1 year after exposure to study the effects of cotton dust exposure and symptoms, lung function Changes and changes in airway responsiveness, and the relationship with specific physical and other factors. Results: The decline of FEV1 after class was small at 10 weeks and 1 year, and the positive of cotton antigen skin test was slightly larger than that of negative. Airway reactivity increased at 10 weeks and remained high at 1 year, especially in skin test positive cases. Sputum and chest tightness and other symptoms gradually increased with prolonged exposure time, and dry cough and nasal irritation and other symptoms at 1 year than 10 weeks decreased. Tip respiratory inflammation reaction with cotton dust exposure time gradually increased, cotton antigen skin test positive reaction heavier.