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目的观察宫颈冷刀锥切术(CKC)对高危型人乳头瘤病毒(HPV)感染宫颈上皮内瘤变(CIN)的疗效。方法选取2012年1月至2013年1月门诊行常规妇科检查、液基细胞学检查(TCT)和HC2 HPV定量检查发现异常,并进一步行电子阴道镜及镜下活组织病理检查诊断为CIN的患者193例,行CKC治疗术,观察其疗效。结果经CKC治疗的高危型HPV感染的CIN患者,术后高危型HPV感染得到清除(P<0.01),术后CIN复发率低,无一例发展成宫颈癌。结论有效的宫颈疾病筛查和及时的CKC术,是治疗高危型HPV感染CIN有效方案,能阻断CIN向宫颈癌发展,但需长期随访。
Objective To observe the effect of cold knife conization (CKC) on high risk human papillomavirus (HPV) infection of cervical intraepithelial neoplasia (CIN). Methods From January 2012 to January 2013, routine gynecological examinations, liquid-based cytology (TCT) and HC2 HPV quantitative tests were performed in outpatient departments between January 2012 and January 2013. Abnormalities were detected by electronic colposcopy and microscopic biopsy to diagnose CIN 193 cases of patients underwent CKC treatment, to observe its efficacy. Results High-risk HPV infection in CIN patients treated with CKC was significantly associated with high-risk HPV infection (P <0.01). The postoperative CIN recurrence rate was low, and none developed cervical cancer. Conclusion Effective screening of cervical diseases and timely CKC surgery is an effective treatment for CIN in high-risk HPV infection and can block the development of CIN to cervical cancer, but long-term follow-up is needed.