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有些抗心律失常的药物若用之不慎易造成严重的不良后果,为此应引起临床用药的重视。 1.盐酸心得安(普萘洛尔)为β—受体阻滞药,主治各种原因所致的心律失常,对于房性和室性早搏效果显著。若用之不慎,可导致心房纤颤。据报道:有例19岁的男性B型预激综合症患者,因用普萘洛尔引起阿—斯综合症而致死。其剂量大可抑制窦房结自律性,中毒时有致命的心动过缓,加之对心肌的负性肌力和扩周围血管作用,使心输出量减少而导致阿—斯综合征。为此,应注意对于心动过缓、重度传导阻滞、低血压及哮喘患者应慎用。普萘洛尔的疗效与剂量有关,随不同适应症而改变,要从小剂量开始,摸索有效治疗量。
Some anti-arrhythmic drugs inadvertently lead to serious adverse consequences, this should lead to the importance of clinical medication. 1. Andean hydrochloride (propranolol) is a β-blocker, attending to various causes of arrhythmia, atrial and ventricular premature beats significantly. If inadvertently, can lead to atrial fibrillation. It is reported: a 19-year-old male patients with pre-excitation syndrome type B, as propranolol caused by Asar Syndrome and died. The dose can inhibit sinus node self-regulation, poisoning, a fatal bradycardia, coupled with the negative myocardial strength and expansion of peripheral vascular function, so that reduced cardiac output and lead to Asin Syndrome. To this end, it should be noted for bradycardia, severe block, hypotension and asthma should be used with caution. Propranolol’s efficacy and dose-related, with different indications and change, starting from a small dose, explore effective treatment.