Flexible strain sensor has promising features in successful application of health monitoring,electronic skins and smart robotics,etc.Here,we report an ultrasensitive strain sensor with a novel crack-wrinkle structure(CWS)based on graphite nanoplates(GNPs)/thermoplastic urethane(TPU)/polydimethylsiloxane(PDMS)nanocomposite.The CWS is constructed by pressing and dragging GNP layer on TPU substrate,followed by encapsulating with PDMS as a protective layer.On the basis of the area statistics,the ratio of the crack and wrinkle structures accounts for 31.8％and 9.5％,respectively.When the sensor is stretched,the cracks fracture,the wrinkles could reduce the unrecoverable destruction of cracks,resulting in an excellent recoverability and stability.Based on introduction of the designed CWS in the sensor,the hysteresis effect is limited effectively.The CWS sensor possesses a satisfactory sensitivity(GF=750 under 24％strain),an ultralow detectable limit(strain=0.1％)and a short respond time of 90 ms.For the sensing service behaviors,the CWS sensor exhibits an ultrahigh durability(high stability＞2×104 stretching-releasing cycles).The excellent practicality of CWS sensor is demonstrated through various human motion tests,including vigorous exercises of various joint bending,and subtle motions of phonation,facial movements and wrist pulse.The present CWS sensor shows great developing potential in the field of cost-effective,portable and high-performance electronic skins.