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大鼠在喂饲高脂高胆固醇饲料的同时，给予有氧运动（游泳）训练７周，观察有氧运动对高脂血症的预防作用并探讨其作用机理。结果发现：有氧运动可显著改善高脂膳食所引起的脂质代谢紊乱，有氧运动组大鼠的血ＴＣ，ＬＤＬ，ＨＤＬ，ＴＧ和Ａｐｏ Ｂ水平都明显低于高脂饲料组，血浆ＡｐｏＡＩ水平明显高于高脂饲料组。运动对高脂所引起的抗氧化能力下降有明显的恢复作用。同时运动可以减少ＬＤＬＲｍＲＮＡ在血管壁的表达，上调ＬＤＬＲ ｍＲＮＡ在肝脏的转录和蛋白表达，减少脂质沉积，促进脂质清除。
The rats were given aerobic exercise (swimming) training for 7 weeks while feeding high fat and high cholesterol feed. The preventive effect of aerobic exercise on hyperlipidemia was observed and its mechanism was explored. The results showed that: Aerobic exercise can significantly improve the lipid metabolism disorder caused by high-fat diet. The levels of TC, LDL, HDL, TG and Apo B in aerobic exercise group were significantly lower than those in high-fat diet group and plasma ApoAI The level was significantly higher than the high fat diet group. Exercise on the decline caused by high fat antioxidant capacity has obvious recovery. At the same time exercise can reduce the expression of LDLR mRNA in the blood vessel wall, upregulate the transcription and protein expression of LDLR mRNA in the liver, reduce lipid deposition and promote lipid clearance.