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INTRODUCTIONrnHigh-risk human papillomaviruses (HPVs) infection is closely associated with the development of female genital epithelial cancers. Over 90％ of cervical cancer biopsies contain high-risk HPV DNA, such as HPV-16 and HPV-18 DNA.1 Many studies have also revealed that HPV is an additional independent risk factor for a subset of head and neck squamous cell carcinoma (HNSCC) patients.