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目的 :目的 :探讨非甾体抗炎药 (NSAIDs)的使用状况及发展趋势。方法 :采用武汉地区 2 1家医院NSAIDs的购入数据 ,应用金额排序法 ,统计分析 2 0 0 0～ 2 0 0 2年购药金额。结果 :NSAIDs的购入金额逐年增加 ;双氯芬酸和布洛芬的购入金额以绝对优势占据NSAIDs市场的前两位 ,但呈下降趋势 ;不良反应较小的新型环氧合酶 2抑制剂的市场份额迅速上升 ,但长期使用的安全性尚待观察。结论 :NSAIDs市场将进一步扩大 ;开发能选择性地抑制外周前列腺素 (PG)的合成又不影响胃肠道等部位的生理PG合成的药物具有广阔的市场前景。
Objective: To investigate the status and development trend of non-steroidal anti-inflammatory drugs (NSAIDs). Methods: Based on the data of NSAIDs purchased from 21 hospitals in Wuhan, the amount of drugs purchased from 2000 to 2002 was statistically analyzed. Results: The purchase amount of NSAIDs increased year by year. The purchase amount of diclofenac and ibuprofen accounted for the absolute superiority of the top two NSAIDs markets, but showed a downward trend. The market share of new cyclooxygenase 2 inhibitors with less adverse reactions Rapid rise, but long-term use of security remains to be seen. Conclusion: The market for NSAIDs will further expand. It is expected that the development of drugs that can selectively inhibit the synthesis of peripheral prostaglandins (PG) without affecting the physiological synthesis of PG in the gastrointestinal tract will have broad market prospects.