• 不 限
  • 期刊论文
  • 硕博论文
  • 会议论文
  • 报 纸
  • 英文论文
  2. 您的位置
  3. 首页
  4. 期刊论文
  5. A Convenient Synthesis of cis and trans-( )-4-Amino-1-[2-(hydroxyl-methyl)-1,3-oxathiolan-5-yl]-2(1H

A Convenient Synthesis of cis and trans-( )-4-Amino-1-[2-(hydroxyl-methyl)-1,3-oxathiolan-5-yl]-2(1H

来源 :中国化学快报（英文版） | 被引量 : 0次 | 上传用户：sadiori1383
【摘 要】
：
A convenient synthesis of cis-(±) isomer 1 and trans-(±) isomer 2 of lamivudine starting from benzoyloxyacetaldehyde and 1,4-dithiane-2,5-diol is described. T
【作 者】
：
Yi SHEN Ling XIANG Yong DENG Y 
【机 构】
：
Department of Medicinal Chemistry
【出 处】
：
中国化学快报（英文版）
【发表日期】
：
2004年期
【关键词】
：
Lamivudine geometrical isomer cis-(±) isomer trans-(±) isomer synthesis 
下载到本地 , 更方便阅读
下载此文 赞助VIP
声明 : 本文档内容版权归属内容提供方 , 如果您对本文有版权争议 , 可与客服联系进行内容授权或下架
论文部分内容阅读
A convenient synthesis of cis-(±) isomer 1 and trans-(±) isomer 2 of lamivudine starting from benzoyloxyacetaldehyde and 1,4-dithiane-2,5-diol is described. The key steps include chlorination of oxathiolane lactol 5 by SOCl2/DMF, followed by coupling with silylated N4-acetylcytosine and deprotection. The overall yield was 42.6 % and 20.1%, respectively.
其他文献
Optical Solitary Waves in Fourth-Order Dispersive Nonlinear Schr(o)dinger Equation with Self-steepen
By making use of the generalized sine-Gordon equation expansion method, we find cnoidal periodic wave solutions and fundamental bright and dark optical solitary
期刊
fourth-order dispersive nonlinear Schrodinger equationbright optical solitary w
A Novel Amperometric Nitric Oxide Sensor Based on Polythionine /Nation Modified Glassy Carbon Electr
A novel amperometric sensor for the determination of nitric oxide was developed by coating polythionine / nafion on a glassy carbon electrode. This sensor exhib
期刊
Amperometric sensornitric oxidethionineelectrochemistry
Catalytic Combustion of Methane over CO1-xMgxO/Al2O3/FeCrAl Monolithic Catalysts
A series of Co1-xMgxO/Al2O3/FeCrAl catalysts (x=0-1) were prepared. The structures of the catalysts were characterized using XRD, SEM, and TPR analyses. The cat
期刊
catalytic combustionmethanemetallic monolithic catalystXRDSEMTPR
THERMOCHROMIC EFFECTS OF LEUCO DYES STUDIED IN POLYPROPYLENE
A series of thermochromic polypropylene foils were prepared by embedding various leuco dye-developer-solvent systems in the polymer matrix. Bisphenol A, laurylg
期刊
ThermochromismDyesExtrusionUV-Vis spectroscopy
Synthesis of a Pair of Derivatives of N-Methylpyrrole Polyamide
A pair of derivatives of tetrameric N-methylpyrrole polyamide were synthesized in order to develop a new method for the study of interaction of the polyamide de
期刊
Synthesispolyamide derivativesultraviolet absorption
A Lower Bound on Unknotting Number
In this paper the authors use a modified Wirtinger presentation to give a lower bound on the unknotting number of a knot in S3.
期刊
Unknotting numberKnotCommutator subgroup
An Abietane Diterpene and a Sterol from Fungus Phellinus igniarius
A new abietane diterpene 12-hydroxy-7-oxo-5, 8, 11, 13-tetraene-18, 6-abietanolide,together with a new natural sterol stigmasta-7, 22-diene-3β, 5α, 6α-triol
期刊
Phellinus igniariusPolyporaceaefungusditerpenesterol
Application of Bipartite Entangled States to Quantum Mechanical Version of Complex Wavelet Transform
We introduce the bipartite entangled states to present a quantum mechanical version of complex wavelet transform. Using the technique of integral within an orde
期刊
entangled statescomplex wavelet transform
Two-Photon Jaynes-Cummings Model Governed by Milburn Equation with Phase Damping
In this paper, we find an analytic solution of the master equation of a non-resonant two-photon JaynesCummings model (JCM) with phase damping with the help of t
期刊
Jaynes-Cummings model (JCM)Milburn equationphase damping
GEOMETRIC OPTICS FOR 3D-HARTREE-TYPE EQUATION WITH COULOMB POTENTIAL
This article considers a family of 3D-Hartree-type equation with Coulomb potential |x|-1, whose initial data oscillates so that a caustic appears. In the linear
期刊
Hartree equationgeometric opticsLagrangian integral