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目的探讨陈旧性心肌梗死后心绞痛的患者微量泵静脉注射地尔硫卓治疗的疗效和安全性。方法 30例陈旧性心肌梗死后心绞痛的病人,经静脉应用硝酸甘油后仍有心绞痛的患者,静脉给予注射地尔硫卓每日1次,连续用3 d。首先按初始剂量1μg/(kg·min)的速度静脉微量泵注入。进一步对陈旧性心肌梗死后患者心绞痛的临床症状缓解程度、心电图及血压的变化、心率及心功能变化进行研究。结果 30例陈旧性心肌梗死后心绞痛患者开始用药后24 h、48 h和72 h,心绞痛明显改善,心电图心肌缺血明显改善,其中10例在用药后24 h心绞痛缓解,22例患者在用药后48 h缓解;72 h后30例心绞痛患者完全缓解,治疗后72 h心电图缺血表现明显改善。对血压、心率无明显影响,对心功能也无影响。结论注射地尔硫卓治疗陈旧性心肌死后心绞痛,是一种安全有效的药物治疗手段。
Objective To investigate the efficacy and safety of intravenous diltiazem in patients with angina after old myocardial infarction. Methods Thirty patients with angina pectoris after old myocardial infarction were treated with intravenous diltiazem intravenously once daily for 3 days after intravenous nitroglycerin and angina pectoris. First, according to the initial dose of 1μg / (kg · min) intravenous micro-pump infusion rate. To further improve the clinical symptoms of angina pectoris in patients with old myocardial infarction, ECG and blood pressure changes, heart rate and heart function changes were studied. Results Angina pectoris was significantly improved at 24 h, 48 h and 72 h after angina pectoris onset in 30 patients with AMI. The myocardial ischemia improved significantly in 10 patients after angina pectoris onset. The angina pectoris was relieved at 24 h in 10 patients and 22 after treatment 48 h relieved; after 72 h, 30 patients with angina pectoris were completely relieved, and the electrocardiogram ischemic performance was significantly improved 72 h after treatment. No significant effect on blood pressure, heart rate, heart function. Conclusion Injection of diltiazem for the treatment of old myocardial infarction angina pectoris is a safe and effective drug treatment.