目前仅有少数有关慢性粒-单核细胞白血病(CMML)染色体研究的资料,且未证实任何特异性的异常。本文首次报道两例CMML有11号染色体三体(+11)的异常。例1,男性,67岁,因白细胞增多和贫血而就诊。体检示肝、脾和淋巴结不肿大。白细胞总数15.3×10~9/L,其中单核细胞占39%。其2-萘酚丁酸酯酶染色呈阳性反应且可为氟化钠所抑制。血清溶菌酶77.4μg/ml。确诊后第5年患者发生急变,给予大剂量阿糖胞苷治疗,未获缓解。例2,男性,56岁,因白细胞增多和贫血入院。体检示肝脾明显肿大。白细胞总数51.3×10~9/L,其中 At present, there are only a few data on chromosome research of chronic myelomonocytic leukemia (CMML), and no specific abnormalities have been confirmed. This is the first report of two cases of CMML with chromosome 11 trisomy (+11) abnormalities. Example 1, male, 67 years old, presented with leukocytosis and anemia. Physical examination showed no enlargement of the liver, spleen and lymph nodes. The total number of white blood cells 15.3 × 10 ~ 9 / L, monocytes accounted for 39%. Its 2-Naphtholbutyrate staining is positive and can be inhibited by sodium fluoride. Serum lysozyme 77.4 μg / ml. In the fifth year after diagnosis, the patient developed rapid change and given high-dose cytarabine treatment without any relief. Example 2, male, 56 years old, admitted to hospital due to leukocytosis and anemia. Physical examination showed obvious enlargement of liver and spleen. The total number of leukocytes 51.3 × 10 ~ 9 / L, of which