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目的了解慢性肾盂肾炎患者的骨代谢情况。方法对３１例慢性肾盂肾炎患者进行了有关骨密度（Ｗａｒｄ’ｓ、Ｎｅｃｋ、Ｔｒｏｃｈ、Ｌ２－４）、血清骨钙素（ＢＧＰ）、尿脱氧吡啶啉（ＤＰＤ）、肾小球滤过率（ＴＧＦＲ）、血β２－ＭＧ、尿β２－ＭＧ等项目的检查，并将结果输入计算机，进行ｔ检验及ｒ直线相关等统计学处理。结果患者组血ＢＧＰ（７．０４１±５．７４３ｎｇ／ｍｌ）、尿ＤＰＤ（６．０５８±２．２４５ｎＭ／ｎＭＣｒ）、Ｗａｒｄ’ｓ三角部位骨密度（０．８３８±０．２２３ｇ／ｃｍ２）与对照组相比（分别为３．３５４±０．７６５ｎｇ／ｍｌ、４．５９６±１．６２１ｎＭ／ｎＭＣｒ、０．９３６±０．０７６ｇ／ｃｍ２）经ｔ检验具有显著差异性（Ｐ＜０．０５或Ｐ＜０．０１）；而Ｎｅｃｋ、Ｔｒｏｃｈ、Ｌ２－４部位骨密度、血清Ｃａ、Ｐ、Ｍｇ、ＡＫＰ、ＢＵＮ、Ｃｒ等项检查，患者组与对照组无明显差异（Ｐ＞０．０５）；患者组Ｗａｒｄ＇ｓ三角部位骨密度与ＴＧＦＲ、血β２－ＭＧ、尿β２－ＭＧ具有明显相关性（ｒ系数分别为０．５６７、－０．５００、－０．３３４，Ｐ＜０．０５）。结论慢性肾盂肾炎患者，即使没有发展到慢性肾功能不全阶段，也已存在骨代谢异常，应及早采?
Objective To understand the bone metabolism in patients with chronic pyelonephritis. Methods Totally 31 patients with chronic pyelonephritis were evaluated for bone mineral density (Ward’s, Neck, Troch, L2-4), serum BGP, DPD, glomerular filtration rate TGFR), blood β2-MG, urinary β2-MG and other items of examination, and the results entered into the computer for t test and r linear correlation and other statistical analysis. Results The serum levels of BGP (7.041 ± 5.743ng / ml), urinary DPD (6.058 ± 2.245nM / nMCr), and Ward’s trigone (0.838 ± 0.223g / cm2) There was significant difference (p <0.05) by t-test in the control group (3.354 ± 0.765 ng / ml, 4.596 ± 1.621 nM / nMCr, 0.936 ± 0.076 g / Or P <0.01). There were no significant differences in the bone mineral density, serum Ca, P, Mg, AKP, BUN and Cr in Neck, Troch and L2-4 patients ). There was a significant correlation between BMD of Ward’s triangle and TGFR, blood β2-MG and urine β2-MG (r coefficient was 0.567, -0.500, -0.334, P <0. 05). Conclusion Patients with chronic pyelonephritis, even if not developed to chronic renal insufficiency stage, there have been abnormal bone metabolism, should be taken as soon as possible?