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目的:为探索形态计量学在病理学诊断中的有效的、参数指标,并比较分形维数与传统的体视学参数中形状因子在定量描述肿瘤细胞核形态不规则程度的敏感性。方法:应用自行研制的“分形分析系统,FAS”和“多媒体彩色病理图文分析系统,MPIAS-500”,收集34例经纤维胃镜活检的人食管癌细胞学涂片,分别观察其正常食管粘膜鳞状上皮细胞核和食管癌细胞核的分形维数与形状因子的改变情况。结果:发现正常食管上皮细胞核和食管癌细胞核边界的分形维数均大于其拓扑维数,即它们都具有分形特征,分别为1.0426?.0167和1.2147?.0428,并且相互之间差异有非常显著性(P<0.01),而形状因子分别为1.053?.104和1.372?.131,相互之间的差异有显著性(P<0.05)。结论:分形维数与形状因子均可定量地描述细胞核形态的不规则程度,分形维数可能较为敏感。分形分析为肿瘤细胞的病理学鉴别诊断提供了一种定量指标,具有一定的实践意义。
OBJECTIVE: To explore the effective parameters of morphometry in the pathological diagnosis and to compare the sensitivity of the shape factor to the quantitative description of the irregularity of nuclear morphology of tumor cells by comparing the fractal dimension and the traditional stereological parameters. Methods: A total of 34 esophageal squamous cell carcinoma smears were collected by using the “Fractal Analysis System, FAS” and “Multimedia Color Pathology Graphic Analysis System, MPIAS-500”. The normal esophageal mucosa The change of fractal dimension and shape factor of squamous cell nucleus and esophageal cell nucleus. Results: The fractal dimension of the nuclear border between normal esophageal epithelial cells and esophageal cancer nuclei was found to be larger than their topological dimensions, that is, they all had fractal features of 1.0426. 0.0167 and 1.2147. 0428, respectively, and the differences between them were significant (P <0.01), while the shape factors were 1.053? .104 and 1.372? .131, the difference was significant (P <0.05). Conclusion: Both fractal dimension and shape factor can quantitatively describe the irregularity of nuclear morphology. Fractal dimension may be more sensitive. Fractal analysis provides a quantitative index for the differential diagnosis of tumor cells in pathology, and has certain practical significance.