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目的观察奥曲肽治疗急性肿瘤性下消化道出血的疗效。方法急性下消化道出血的肿瘤患者47例,分为治疗组22例,对照组25例,在输血、补液、一般止血药物治疗的基础上,治疗组加用奥曲肽首剂0.25 mg静脉推注,然后以0.25 mg.h-1静脉滴注维持至出血停止后24 h;对照组加用垂体后叶素0.2 U.m in-1静脉滴注,出血停止后减量为0.1 U.m in-1维持24 h。结果治疗组总有效率81.8%,对照组总有效率52.0%(P<0.05)。结论奥曲肽治疗急性肿瘤性下消化道出血疗效显著,安全性好。
Objective To observe the efficacy of octreotide in the treatment of acute tumorous lower gastrointestinal bleeding. Methods Forty-seven patients with acute gastrointestinal bleeding were divided into treatment group (n = 22) and control group (n = 25). On the basis of transfusion, rehydration and general hemostasis, the treatment group was given 0.25 mg intravenous injection of the first dose of octreotide, Then treated with intravenous infusion of 0.25 mg.h-1 until 24 h after the stop of bleeding. In the control group, intravenous infusion of 0.2 Um in-1 of vasopressin was added to the control group. After the bleeding stopped, the volume was reduced to 0.1 Um in-1 for 24 h . Results The total effective rate was 81.8% in the treatment group and 52.0% in the control group (P <0.05). Conclusion octreotide treatment of acute tumor of lower gastrointestinal bleeding significant effect, good safety.